Of course, the Citizens squad is better placed than most to deal with injuries, but the Frenchman had been one of their most impressive performers this season. He has been reborn under the guidance of Manuel Pellegrini.
The Chilean may even look to alter his setup and formation as his team enter crucial games in four different competitions over the next few weeks, but who are the players he'll be relying upon?
Different members of his squad might be required to play in varying positions in the team as the matches stack up over the next few weeks.
Here are six players whose roles at City could be about to become more important.