Arsenal can stretch their lead at the top with victory at Southampton.
With the FA Cup over for another few weeks, the Premier League rightly takes precedence once again.
There are only 16 games left of the season, so any points picked up now are likely to have relevance later in the season.
The chasing pack are within touching distance and waiting to feed on any scraps that may come their way, setting everything up nicely for another fascinating instalment.
Let's take a look at some predictions and where you can get your football fix.
|Crystal Palace vs. Hull City||Jan 28||8 p.m. GMT/3 p.m. ET||1-0|
|Liverpool vs. Everton||Jan 28||8 p.m. GMT/3 p.m. ET||2-2||BT Sport||BT Sport App|
|Manchester United vs. Cardiff City||Jan 28||7.45 p.m. GMT/2.45 p.m. ET||3-1|
|Norwich City vs. Newcastle United||Jan 28||7.45 p.m. GMT/2.45 p.m. ET||0-3|
|Southampton vs. Arsenal||Jan 28||7.45 p.m. GMT/2.45 p.m. ET||1-2|
|Swansea City vs. Fulham||Jan 28||7.45 p.m. GMT/2.45 p.m. ET||2-1|
|Aston Villa vs. West Brom||Jan 29||7.45 p.m. GMT/2.45 p.m. ET||1-1|
|Chelsea vs. West Ham United||Jan 29||7.45 p.m. GMT/2.45 p.m. ET||5-0|
|Tottenham Hotspur vs. Manchester City||Jan 29||7.45 p.m. GMT/2.45 p.m. ET||2-3||BT Sport||BT Sport App|
|Sunderland vs. Stoke City||Jan 29||7.45 p.m. GMT/2.45 p.m. ET||1-0|
Viewers in the United States can watch a number of Premier League games via the NBC Sports Live Extra app, but this service is not available to viewers in the UK.
Southampton vs. Arsenal
Mauricio Pochettino surprised a lot of people when guiding Southampton to the upper echelons of the Premier League, and although the Saints have dropped off the pace, they still remain in a respectable ninth position.
The resignation of Chairman Nicola Cortese could yet see Southampton's season fall apart altogether, but for the meantime, Pochettino has full control over his wonderfully engaging band of young players.
Their usual attacking 4-3-3 formation will take the game to the Gunners, who need to be alert to the dangers that Southampton possess right across the pitch.
Adam Lallana is the fulcrum of the side, his creative excellence allowing Jay Rodriguez, Morgan Schneiderlin et al to flourish.
It's a brand of attacking football delivered with zip and zest and Arsenal need to be at their best to take the three points.
Can Arsenal go all the way to the title this season?
Arsene Wenger is likely to keep to a 4-2-3-1, allowing Mesut Ozil a free role in behind Olivier Giroud. In order to pick up Ozil, Lallana is forced across the pitch opening up the channels for Santi Cazorla and Jack Wilshere to be at their devastating best.
It will be tight, but the Gunners should see this one out by the odd goal to retain their position at the top of the pile.
Prediction: Southampton 1-2 Arsenal
Norwich City vs. Newcastle United
Only two goals in their last six outings gives you an idea of the task facing Norwich manager Chris Hughton.
Gary Hooper, signed in the summer from Celtic, has managed a reasonable seven goals so far this term, but the next-best marksmen is Leroy Fer on just four.
Ricky van Wolfswinkel has been anything but the superstar striker Hughton would have you believe he was signing, having only found the net once on the opening day of the season.
Although only four places separate the Canaries from Newcastle, the difference in class is marked.
Alan Pardew can call upon the effortless guile and natural ability of Yohan Cabaye to pick the lock, whilst Loic Remy is beginning to find the goalscoring form for which he was noted at Marseilles.
Yoan Gouffran is another able supplementary attacking presence for the Magpies.
Even if those three are all off colour, which is highly unlikely, Norwich still need to find a way past brick wall Cheick Tiote, a solid back four, and in Tim Krul, a goalkeeper at the top of his game.
Prediction: Norwich City 0-3 Newcastle United
Tottenham Hotspur vs. Manchester City
What a delightful and mouth-watering contest we have in prospect at White Hart Lane.
The two form teams in the division going head to head is unlikely to be a game for the faint-hearted, but certainly one for the purist.
Manuel Pellegrini's swashbuckling Manchester City side are taking on all before them at the moment, with an astonishing 103 goals in all competitions serving to highlight their attacking prowess.
Alvaro Negredo is scoring for fun at the moment, but City have at least five players already into double figures for the season.
Although Tottenham will prove to be a different proposition to the team that was on the end of a 6-0 hammering at the Etihad, their defence will need to be at its very best against a team that can, and does, score from anywhere.
Tim Sherwood has entered the record books as the Tottenham manager with the best ever start in the club's history and Emmanuel Adebayor is just one player that is like a new man under the tutelage of the former Spurs midfielder.
The twin pivot of Nabil Bentaleb and Mousa Dembele sit just in front of the Tottenham back four and may well decide the outcome of this game.
If the pair can restrict the creative meanderings of David Silva and harness the raw power and boundless energy of Yaya Toure, then Spurs could spring a surprise.
Prediction: Tottenham Hotspur 2-3 Manchester City