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Could Harry Kane benefit from Defoe's departure?
Despite Defoe generally being a good performer for Tottenham over the years, he has not scored so regularly over the last year that the club was desperate to keep him around.
In fairness to Defoe, injury hurt his momentum early in 2013. This season, the arrival of Roberto Soldado and Andre Villas-Boas' preference for using a lone striker made starting opportunities in the right circumstances hard to come by.
Nonetheless, when Defoe did have chances, he did not always make the most of them.
His leaving gives Spurs an opportunity to try something or someone new up front. In the short term, that might not be much more than academy product Harry Kane seeing his own first-team playing opportunities increase.
Heading into the summer and next season, the possibilities will truly begin to emerge.
No matter Spurs' situation, there is a strong likelihood that they will look into the transfer market for a new striker. The success of their current crop of forwards will also influence just how much they spend and the type of attacker they look to recruit.
Sherwood (if he is still in charge) will have scope to engineer his own approach to his team's attack moving forward.
Stylistically, there is more room to breathe now too. In the current climate of Premier League strikers, a primary poacher like Defoe is comparatively old-fashioned.
While Soldado's presence will ensure they do not move too far away from here, Spurs could try something a little different if they so desire.