All eyes will be on Stamford Bridge on Sunday as Chelsea play host to Manchester United in the biggest game in the English top flight this weekend.
United ended a three-game losing sequence with their win over Swansea City last week, while the Blues are on a run of four successive league wins.
Leaders Arsenal are at home to Fulham on Saturday, and Manchester City entertain Cardiff City.
Aston Villa travel to Liverpool for the late kick-off on Saturday, with Everton lining up at West Bromwich Albion on Monday.
Here is the latest team news for all the weekend's Premier League games.
Sunderland vs. Southampton
Carlos Cuellar and Keiren Westwood are still out for Sunderland, and manager Gus Poyet may keep the same team which beat Fulham last weekend.
Dani Osvaldo serves the last match of a three-game suspension for Southampton, while Victor Wanyama (calf) and Guly do Prado (knee) are still out.
Arsenal vs. Fulham
Arsenal defender Thomas Vermaelen is expected to return to the squad after a knee injury, but midfielder Tomas Rosicky is likely to miss out with a suspected broken nose. Aaron Ramsey is still out, but Mikel Arteta could return. Nicklas Bendtner and Abou Diaby remain sidelined.
Brede Hangeland and Maarten Stekelenburg return from injuries for Fulham, while Scott Parker is back after being rested for the FA Cup replay win over Norwich City.
Crystal Palace vs. Stoke City
Kagisho Dikgacoi is rated doubtful with a calf injury, while Yannick Bolasie also faces a late fitness test on a groin problem.
Oussama Assaidi returns for Stoke after being unable to play against parent club Liverpool last weekend. Goalkeeper Thomas Sorensen could be back after an Achilles injury, but Asmir Begovic and Robert Huth are still out.
Manchester City vs. Cardiff City
Sergio Aguero is back for Manchester City after a substitute appearance in the FA Cup replay against Blackburn. Midfielders Yaya Toure and David Silva are doubts for the game.
Jordon Mutch is a doubt for Cardiff with a hamstring problem, but new signee Magnus Eikrem could make his full debut.
Norwich City vs. Hull City
Norwich have no fresh injury concerns but will still be without Jonny Howson, Anthony Pilkington and Alexander Tettey.
Hull could give Nikica Jelavic his debut, but Robbie Brady (groin), Sone Aluko (Achilles) and Paul McShane (ankle) are still absent.
West Ham United vs. Newcastle United
West Ham defenders Guy Demel and Joey O'Brien are rated doubtful, while James Tomkins is suspended. James Collins could return along with Ricardo Vaz Te, while Kevin Nolan serves the last game of a three-match suspension.
Newcastle manager Alan Pardew has no fresh injury concerns, with long-term casualty Ryan Taylor his only absentee.
Liverpool vs. Aston Villa
Liverpool striker Daniel Sturridge is set to start after making a return at Stoke last weekend. Mamadou Sakho could also feature after injury, but Daniel Agger, Jose Enrique, Jon Flanagan and Joe Allen all remain sidelined.
Nathan Baker is a doubt for Aston Villa after suffering a mild concussion against Arsenal, while Joe Bennett is also available again. Charles N’Zogbia and Jores Okore are both still out.
Swansea City vs. Tottenham Hotspur
Jose Canas is rated doubtful for Swansea with possible ankle ligament damage, but Jonathan de Guzman could return after a calf injury. Roland Lamah returns after a stomach muscle problem, while Nathan Dyer and Pablo Hernandez could also feature. Goalkeeper Michel Vorm is still out.
Tottenham have doubts over Erik Lamela and Kyle Walker, but Younes Kaboul and Jan Vertonghen are still sidelined.
Chelsea vs. Manchester United
Frank Lampard could return for Chelsea, but Branislav Ivanovic is ruled out.
Wayne Rooney is a doubt with a groin injury, while Jonny Evans, Rio Ferdinand and Patrice Evra are doubtful. Robin van Persie remains sidelined.
West Bromwich Albion vs. Everton
Victor Anichebe remains doubtful for the visit of his former club with a groin problem.
Antolin Alcaraz misses out for Everton, but Sylvain Distin is expected to return. Gerard Deulofeu remains sidelined with a hamstring injury.