The two sides finished with a 1-1 draw on Jan. 4, leading to this replay to decide the winner. Although the home squad remains the favorite to advance, the first battle proved that either side is capable of advancing to face Watford in the next round.
Blackburn have certainly showcased their ability as of late with only one loss in the last seven Championship matches. Meanwhile, Manchester City has nine wins in its last 10 matches in all competitions. Only the draw in this first matchup has prevented a perfect stretch.
Both sides will fight hard to stay in contention for this prestigious trophy, so make sure you catch every minute of the action.
When: Wednesday, Jan. 15
Time (U.S.): 3:10 p.m. EST
Time (U.K.): 8:10 p.m. GMT
Watch (U.S.): Fox Deportes, Fox Sports 2
Watch (U.K.): ITV HD
Live Stream: Fox Soccer 2 Go
Odds (via SkyBet): Manchester (1-7), Blackburn (18-1), Draw (8-1)
Top Storyline: Will Sergio Aguero Make an Impact Upon His Return?
One of Europe's top scorers is expected to be back in action for Manchester City after missing the past month with a calf injury, according to BBC Sport:
Richard Jolly of ESPN FC quoted manager Manuel Pellegrini about the return of Aguero, saying, "It doesn’t matter that we are scoring a lot of goals. Sergio will always be an important player. We are very happy he is coming back."
After scoring 12 league goals all last season, Aguero already has 13 for Manchester City, which trails only Luis Suarez for the EPL lead. He also ranks third in Europe with six goals in Champions League play.
While Alvaro Negredo and Yaya Toure have taken over as scorers, the return of Aguero will be huge as City look to contend for multiple trophies.
The question is how much of an impact the striker can make right away. He is listed as part of the squad, but it is unknown if he will start or whether he will come in as a substitute. As long as he gets onto the pitch at some point, he is likely to make his presence known in this match.
Prediction: Manchester City 3, Blackburn Rovers 1
Although Blackburn Rovers did a great job of containing Manchester City the first time these teams played, it will be a much different story at the Etihad Stadium. Opta Joe provides a look at how good City have been at home recently:
Meanwhile, Blackburn have struggled themselves away from home, as noted by WhoScored.com:
City have simply too many weapons to defend, even if Pellegrini decides to rest some of his key players. The offense will be aggressive and will find ways to get the ball in the back of the net.
Jordan Rhodes should be able to find a way to get free for Blackburn to get onto the scoresheet, but it will not be enough to remain competitive in this match.
Follow Rob Goldberg on Twitter for the latest breaking news and analysis.
Like the new article format? Send us feedback!