Manchester United will be looking for revenge when they play host to Swansea City on Saturday in the Premier League, less than a week after being dumped out of the FA Cup by Michael Laudrup's side.
United will be aiming to end a run of three successive defeats, while league leaders Arsenal travel to Aston Villa on Monday without Theo Walcott, who has been ruled for the rest of the season after suffering a serious knee injury against Tottenham last weekend.
Second-placed Manchester City are at Newcastle United on Sunday, while Hull City entertain Chelsea.
Here's the latest team news for the weekend matches.
Hull City vs. Chelsea
Stephen Quinn returns for Hull, but Sone Aluko (Achilles) and Robbie Brady (groin) remain sidelined.
Frank Lampard and Branislav Ivanovic are expected to miss out for Chelsea.
Cardiff City vs. West Ham United
Kevin Theophile-Catherine (knee) and Jordan Mutch (hamstring) are doubtful for Cardiff, while Andrew Taylor and Craig Bellamy remain sidelined. New signing Magnus Eikrem could make his debut.
Kevin Nolan is suspended for West Ham, but Ravel Morrison returns from a hamstring injury. Defenders James Collins and James Tomkins remain sidelined by calf and groin problems, respectively. Full-back Joey O'Brien is a doubt with a knock picked up at Manchester City on Wednesday.
Everton vs. Norwich City
Everton will make a late decision on Ross Barkley, who has a toe injury, while defenders Sylvain Distin and Phil Jagielka both face late fitness tests. Leighton Baines is doubtful with a back problem.
Michael Turner and Sebastian Bassong face late fitness tests for Norwich, while Bradley Johnson is also doubtful. Leroy Fer returns from suspension, but Anthony Pilkington remains on the sidelines.
Fulham vs. Sunderland
Clint Dempsey is set for his second home debut for Fulham, but defender Brede Hangeland is still unavailable through injury. Goalkeeper Maarten Stekelenburg is poised to return from an ankle injury.
Sunderland welcome defenders John O'Shea and Wes Brown back to the squad, while new signing Marcos Alonso could make his Premier League debut.
Southampton vs. West Bromwich Albion
Southampton striker Rickie Lambert is doubtful with a dead leg, but Gaston Ramirez should be fit. Dani Osvaldo is suspended, but Nathaniel Clyne could return. Victor Wanyama (calf), Artur Boruc (hand) and Guly Do Prado (knee) remain sidelined.
West Brom striker Victor Anichebe could return after missing the last five games with a groin injury. Youssouf Mulumbu and Billy Jones face late fitness tests.
Tottenham Hotspur vs. Crystal Palace
Crystal Palace manager Tony Pulis has no fresh injury concerns with Adlene Guedioura and Jerome Thomas still sidelined by injury.
Manchester United vs. Swansea City
Marouane Fellaini and Phil Jones remain sidelined for Manchester United, while Wayne Rooney is also after being afforded a rest. Rio Ferdinand is out with a knee injury, but Rafael is set to continue after recovering from an ankle problem. Robin van Persie is still out, and Fabio is suspended.
Swansea striker Michu is still out following ankle surgery, while Roland Lamah (abductor) and Pablo Hernandez (hamstring) are also absent. Nathan Dyer and Michel Vorm remain sidelined.
Newcastle United vs. Manchester City
Newcastle midfielder Yohan Cabaye is rated doubtful with an ankle injury, but goalkeeper Tim Krul is likely to return after a shoulder problem. Mathieu Debuchy is suspended, and Fabricio Coloccini will be out for several weeks with a knee problem.
Manchester City midfielder David Silva returns from suspension, but winger Jesus Navas is a slight doubt with a knee injury. Midfielder Yaya Toure faces a late fitness test on an ankle problem.
Stoke City vs. Liverpool
Stoke City goalkeeper Thomas Sorensen is doubtful with an Achilles injury, which could see Jack Butland make his full Premier League debut for Mark Hughes' team. Striker Oussama Assaidi is unable to play against his parent club, meaning Marko Arnautovic could return from illness. Asmir Begovic and Robert Huth remain sidelined.
Liverpool striker Daniel Sturridge could return after an ankle injury, but defender Daniel Agger is out. Mamadou Sakho could return after injury. Glen Johnson is back to full fitness, but Joe Allen is still out. Steven Gerrard could make his league return after playing against Oldham in the FA Cup last weekend.
Aston Villa vs. Arsenal
Aston Villa defender Ciaran Clark returns from suspension, but striker Libor Kozak has been ruled out for the season with a broken leg. Nathan Baker, Gabriel Agbonlahor and Ron Vlaar are all doubtful, while Charles N'Zogbia and Jores Okore are long-term absentees.
Arsenal will be without Theo Walcott for the rest of the season due to a knee injury, while Kieran Gibbs has a calf problem. Striker Olivier Giroud returns from illness along with Mesut Ozil, while Alex Oxlade-Chamberlain could be in contention after a long-term injury. Aaron Ramsey (thigh), Nicklas Bendtner (ankle) and Abou Diaby (knee) are still out.