The Celtics played the Thunder close in the first half and battled a bit in the third quarter, but Oklahoma City eventually pulled away, shooting 52 percent from the floor.
Boston shot the ball very well from beyond the arc, going 11-of-23, but overall, the C's hit on only 44 percent of their field-goal attempts.
Jeff Green and Avery Bradley were the Celtics' high scorers with 19 apiece.
This marks the fourth straight loss for Boston, which is now in the middle of a brutal five-game road trip.
OKC is now 4-2 since Russell Westbrook went down with knee surgery.
Let's break down the keys to this one.
Reggie Jackson Getting Easy Shots
Jackson managed to get tons of good looks in the win, particularly in transition.
As evidenced by his 9-of-12 clip, Jackson was able to get plenty of shots at the rim, and the Thunder did a great job of spreading the floor which led to him being able to knock down all three of his long-range attempts.
Jackson dictated the pace of this one from the get-go, and on a night where Durant appeared to be a bit off and maybe fatigued, OKC needed that type of performance from its floor general.
The Thunder only turned the ball over nine times in this one, with Durant not committing a single giveaway.
On the flip side, the Celtics coughed up the rock 16 times, and Oklahoma City was able to take advantage of those miscues to get out in transition.
The Thunder went 24-of-31 from the charity stripe while Boston shot only 15-of-24. Durant went 9-of-10 from the line and Jackson went 6-for-9.
For Boston, both Jared Sullinger and Gerald Wallace missed three free throws, Sullinger going 3-of-6 from the stripe and Wallace going 1-of-4.