Where: The Emirates Stadium
When: Saturday, 4 January, 5:15 p.m. GMT
The marquee third-round tie is undoubtedly the North London derby, pitting two heavyweights of the FA Cup against each other: Arsenal and Tottenham.
Tim Sherwood takes his newly inherited squad to the Emirates to challenge Arsene Wenger's table-topping Gunners.
Together these two sides have won 18 FA Cups between them, and only Manchester United have lifted the trophy more.
FA Cup Highlights
Arsenal: 10-time winners (1930, 1936, 1950, 1971, 1979, 1993, 1998, 2002, 2003, 2005).
Tottenham: Eight-time winners (1901, 1921, 1961, 1962, 1967, 1981, 1982, 1991).
Both clubs are in consistent domestic form, taking 10 points from their past four games.
This fixture has already been played this season with an Olivier Giroud strike earning Arsenal a vital 1-0 win in September.
The Gunners have won four of the past five clashes with their rivals on home soil.
Prediction: Arsenal 2-0 Tottenham
Arsenal will be expected to advance and—regardless of Wenger's likely rotation—will still have enough to halt Spurs' momentum under Sherwood.
The away side have more injury worries to contend with and don't have the strength in defence to combat Arsenal's attacking midfielders.
Sherwood has been especially adventurous during his short managerial career. His 4-4-2 is yet to be exploited, although Arsenal seem the side most suited to expose it.