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All of Everton's absentees were missed during this game.
Howard's presence and Jagielka's leadership left the defence feeling more vulnerable, while no Mirallas and Pienaar resulted in a lack of creativity during the early stages.
However, no absence was felt more than Gareth Barry's.
The England midfielder has already become integral to his new side, and without his presence, the Toffees struggled on and off the ball.
The midfield was too accommodating without possession, providing too much space for Southampton to exploit, but it was the passing game that was left most depleted.
Barry has been Everton's leading passer in 10 of his 14 games and in all of the last six fixtures, often by a considerable margin. He's responsible for moving his side around, and without his influence, Everton lacked imagination and often surrendered possession cheaply.
Without Barry dictating the tempo, the Toffees recorded 27 fewer passes than in any match this season and also averaged under 50 percent possession in a home game (45 percent) for just the second time under Martinez (having previously done so against Chelsea).
These numbers are all a direct result of Barry's absence from the Toffees' core and suggest his side were slightly fortunate to win—the first time they have done so without him.
Thankfully his suspension is just for one match, but this again emphasises just how vital it is that his loan becomes a long-term deal.