The festive fixture, an away trip doubleheader, couldn't have been much worse for Brendan Rodgers' side, who were unlucky to not have been the first team this season to leave Eastlands with at least a point.
Rodgers' side will be seeking to end Jose Mourinho's unbeaten Premier League record at home, and they can draw inspiration from their visit to Stamford Bridge in 2008, when they broke the Blues' 86-game unbeaten run at home in the Premier League, courtesy of Xabi Alonso's goal.
Liverpool are without captain Steven Gerrard, full-backs Jose Enrique and Jon Flanagan, former Chelsea striker Daniel Sturridge and Victor Moses—who is ineligible due to being on loan from the Londoners.
With such a huge fixture coming so soon after the tough match at City, will Rodgers be tempted to change his pack?
Here's the key decisions facing the manager ahead of the big match.