The two sides have shared some classic encounters down the years, especially in the past decade.
Their rivalry was ignited upon the appointments of Iberian duo Rafa Benitez and Jose Mourinho in the summer of 2004.
The Spaniard and Portuguese manager's lined up an incredible 16 times from 2004 to 2007; meeting in FA Cup semi-finals, League Cup finals, Champions League group stages, quarter-finals and semi-finals.
Mourinho had the better of the duels overall via a superior Premier League record against Rafa's Reds, but Benitez got the best of his foe in cup competitions.
Overall, Mourinho won seven times, Benitez won five, and there were four draws. Mourinho's Chelsea scored 16 goals and Benitez's Liverpool scored 12 (stats via Manuel Traquete for B/R).
Of course, there were many classic meetings before then and since; here's 20 of the best Chelsea vs. Liverpool encounters.