With Liverpool's victory over Cardiff on Saturday, the Gunners need a result to ensure that they will be top of the table at Christmas instead of their Merseyside rivals. For Chelsea, it is all about keeping well and truly in the hunt for the title.
They have served up some classic clashes in the league over recent years, with controversy, goals and incidents galore in what is usually a hectic affair.
Let's take a look at five of the best Arsenal vs. Chelsea clashes in the history of the Premier League, with some notable games included.
Having just come off the back of an unbeaten season and being crowned champions of England, Arsenal were once again expected to be amongst the runners and riders for the title.
Despite the game finishing 2-2 in another highly entertaining affair between the sides, the game is perhaps most fondly remembered for another moment of genius from Thierry Henry.
With Chelsea still adjusting their wall prior to a free-kick, Henry was too quick for the Blues defence, bending the ball around the wall to the fury of the Chelsea side.
However, that season it was to be Chelsea, not Arsenal, who would lift the Premier League trophy.
Prior to this game, Arsenal's record against the two dominant forces in the Premier League was appalling. They had not beaten Chelsea or Manchester United for 11 consecutive matches, and they had lost 10 of those.
They had not beaten Chelsea for well over two years in all competitions, but it all changed in December 2010 as Cesc Fabregas stole the show.
He and Theo Walcott were magnificent, and they scored the second and third goals just minutes into the second-half to confirm the result early on.
Although that season would ultimately end without silverware for the Gunners, it was a great night for Arsenal fans.
Arguably the transfer story of 2006 was Ashley Cole's sensational switch between Arsenal and Chelsea. Although the Gunners got cash plus William Gallas for the England left-back, it wasn't enough for Arsenal fans.
So, when they visited Stamford Bridge in the 2006-07 season, they showed their dissatisfaction for Cole by throwing fake £20 notes into the air.
On the pitch, Cole's first appearance against his former club was salvaged by a stunning strike from Michael Essien, after Mathieu Flamini had put the Gunners in front.
It was a high octane atmosphere, with tempers flaring throughout. It was a fantastic game to watch, though.
It was the ultimate comeback in a game of this atmosphere, and it was orchestrated by the sublime Nwankwo Kanu.
With 15 minutes left, Chelsea were leading 2-0 and seemingly cruising against the Gunners. Cue the Nigerian, who turned the game on its head with one of the best individual performances in Premier League history.
The first two goals were special enough, but the third was remarkable. With Ed de Goey racing out of his area needlessly, Kanu bent the ball home from the most ridiculous of angles to send the travelling fans delirious.
That day, it was all about Kanu.
Robin van Persie stole the show in 2011, as his goals tally kept getting better and better as he bagged three at Stamford Bridge.
Arsenal were superb on the day, with Andre Santos and Theo Walcott also finding the back of the net as the Gunners ran riot in west London, in a superb advert for Premier League football.
It makes the top of the list because it was a remarkable game of football to watch, with chances at both ends throughout, illustrated by the fact Chelsea also netted three times.
It could have been 10-10 in truth, but it was another dark day for Andre Villas-Boas in his ultimately short tenure at Chelsea.