Tim Sherwood's first Premier League game in charge saw his Tottenham side go a goal down after Adam Lallana duped Vlad Chiriches and fired in a precise, long-range effort.
Spurs equalised just over 10 minutes later through a terrific counter-attack. Erik Lamela cleared to Emmanuel Adebayor, who found Roberto Soldado's run out left. The Spaniard's subsequent cross picked out the charging Adebayor's run, with the striker scoring with a scissor-kick.
Jos Hooiveld gave Spurs a second-half lead after deflecting Danny Rose's cross into his own net, but Southampton responded within five minutes.
The impressive Lallana got in behind the visitors' defence and made the most of Hugo Lloris' kamikaze charge from goal, picking out Rickie Lambert with an open goal in front of him to make the score 2-2.
It was to be Spurs' own star man Adebayor who won the game. Benefiting from the persistence of substitute Nacer Chadli, he tucked the ball away to seal the win.
In the meantime, here are some things we learned from Sunday's match.