Manuel, who played through a knee sprain in last week's game against Jacksonville, delivering a solid fantasy line, has been ruled out for this week with the same knee injury. Thaddeus Lewis will start at quarterback for the Bills in his place.
It's possible Manuel will return to the lineup for the final week of the season. The rookie actually put together his best fantasy effort of the year last week, totaling a season-high three touchdowns (two passing, one rushing).
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