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Ruben Garcia was on target for Levante in the 4-0 win over Recreativo Huelva.
Levante 4-0 Recreativo Huelva (agg: 4-1)
Levante made no mistake in the return after slipping to a 1-0 defeat to the second-tier Recreativo Huelva in the first match.
Simao Mate, Ruben Garcia, Andreas Ivanschitz and David Barral were all on target in a 4-0 win, which sent the La Liga side through on a 4-1 aggregate.
Granada 0-2 Alcorcon (agg: 2-2, Alcorcon win 5-4 on penalties)
The biggest surprise of the night came as Alcorcon overturned a two-goal deficit to defeat Granada 5-4 on penalties.
Verdes headed home in the 40th minute to give the visitors hope of remaining in the tie, and Nagore levelled the match with nine minutes of normal time remaining.
Extra-time could not separate the two teams, and the tie went to the lottery of a penalty shoot-out.
Both sides scored from their opening four spot-kicks, but after Jony had put Alcorcon 5-4 ahead, Jeison Murillo missed for the La Liga side.
Elche 0-1 Villarreal (agg: 2-3)
Villarreal striker Jeremy Perbet scored the only goal of the game to knock Elche out of the competition.
The home side had claimed a creditable 2-2 draw from the first leg, but were unable to claw back the deficit after Perbet's 58th-minute strike.
Getafe 4-1 Girona (agg: 5-2)
Getafe lined up a last-16 clash with Barcelona after a thumping 4-1 win over Girona.
Pablo Sarabia, Adrian Colunga, Angel Lafita and Lisandro Lopez were all on target as the home side swept away their opponents.