Napoli will hope to build on their superb victory over Arsenal in the Champions League on Wednesday rather than feel sorry for themselves after they were cruelly dumped out of the competition, despite amassing 12 points.
In a huge game, the Partenopei face Inter, which will see Walter Mazzarri face his old team for the first time.
Rafael Benitez knows that Inter could be one of their rivals for a place in the top three and will hope to win this game in order to refocus attention on catching Juventus at the top of the table.
Inter, on the other hand, will hope that a positive run of results in the remaining games before Christmas can leave them in a good position before investing heavily in January to boost their hopes of qualifying for the Champions League next season.
Here are some of the key tactical duels that await us.