Where: City of Manchester Stadium
When: Saturday 14 December, 12:45 GMT
The weekend kicks off with a heavyweight clash between Premier League favourites, Manchester City, and the current leaders, Arsenal.
It also pits the division's best home record against the most successful travellers.
Manuel Pellegrini's side have an unblemished record at the City of Manchester Stadium with seven wins out of seven, scoring an incredible 29 goals and conceding just two. Arsenal's impressive 16-point haul from their seven away games is similarly impressive.
Both sides have been in strong form of late, collecting 13 points from their past six games.
They sit second and third in the form table, respectively, having both won three of their last four Premier League fixtures.
This game was drawn 1-1 last season, although City hold three wins and a draw from the Gunners' previous five Premier League visits.
Both sides faced tough midweek away trips in the Champions League and are likely to make changes.
Manchester City will look to soak up possession on home soil, stretch the field and work the ball into the box, while Arsenal may be content to play on the break.
The Gunners surrendered the ball to Everton for much of their previous game yet were rarely exposed and created most of the game's best chances.
Sergio Aguero's battle and success against the league's best defence will be intriguing viewing as will Aaron Ramsey's clash with Yaya Toure for midfield supremacy.
Prediction: Manchester City 2-1 Arsenal
Arsenal have surprised most people with their consistency this season, but this is their toughest test of the season. They will struggle to take much from Manchester.