Gokhan Inler will be the man with the toughest job on the pitch come Wednesday night. The 29-year-old highly disciplined Swiss international is a conventional box-to-box midfielder, but he also excels in a defensive role for club and country.
Considering that Marek Hamsik will miss the match, much of the midfield onus will be placed upon Inler. His ability to read the game from a defensive standpoint makes him the ideal man to go toe-to-toe with Mesut Ozil.
Inler's main job will be to patrol the central midfield area in front of his back four. If he can control this area and force Ozil out wide, the German's influence will lessen. However, if Ozil can gain the upper hand then Napoli are in for a long night as the likes of Tomas Rosicky, Santi Cazorla and, lest we forget to mention, the irrepressible Aaron Ramsey will bomb forward to support Ozil and Olivier Giroud.
Central midfield will become the battle ground where this game is won and lost.
Inler, like Mikel Arteta, is exceptional in possession and rarely gives the ball away. Unlike Arteta, however, he likes to use long passes to the likes of Lorenzo Insigne and Jose Callejon. Ozil will have to be aware of this potential weapon. If there is a weak point to his game it can be found in the fact that he can give away needless free kicks.
Ozil will need no introduction to Arsenal or Napoli's fans. The German has all the skills needed to be a world-class No. 10. He works incredibly hard, both defensively and offensively, and is always available to receive the ball regardless of the danger surrounding him. He is one of the bravest players in the Arsenal line-up and never shirks his duty.
Inler will look to make his midfield battle with Ozil a war of attrition as the German is simply not built for those conditions. However, Ozil is far too intelligent a player to fall for such base tactics. Inler will therefore need to impose his game upon the Arsenal man by other means.
The battle to control midfield will be extremely tight.
Arsenal knows that if they score just one goal then the match is all but over.
Expect the Gunners to tear into Napoli right from the off, with Benitez's team trying to catch the Gunners on the break as they try to weather the storm.
The first 20 minutes will be key and the foundation for victory will be laid by Inler and Ozil in what could prove to be an incredibly exciting match.