According to The Guardian's Jamie Jackson, Ferdinand told BT Sport that the Scot's policy when it comes to picking his team can often leave him feeling like "a madman."
The centre-back was brought to the club by Sir Alex Ferguson in 2002 and enjoyed an extremely fruitful alliance with the United figure, who is now in a directorial position with the club.
Ferdinand has been a leading influence at the Theatre of Dreams for more than a decade now, helping the club to six Premier League titles, a Champions League crown, a FIFA Club World Cup and more.
Samuel Luckhurst of the Huffington Post published further comments the defender made to BT Sport:
This manager's a bit different in that he doesn't name the team beforehand. You don't really get to know the team. The old manager used to give you a kind of a little bit of an idea if you'd be playing and stuff.
When you know you're playing the intensity goes up a little bit more on matchday and that's what you need to try and make sure you're doing even if you don't know you'll be playing to try and get to that intensity you'd be at when you know you're playing.
It's hard. It's hard to do that mentally because you spend a lot of nervous energy thinking 'Am I playing?' or 'Am I not playing?' and you're just going round in circles in your head and turning into a madman.
Moyes was always going to have a difficult run of things in replacing Ferguson as the helmsman at United—the latest sign of how hard times have become being the midweek loss at home to his former club Everton.
Following that result, the reigning league champions now sit 12 points adrift of top spot in ninth and it looks increasingly unlikely that the 2013/14 campaign will produce a successful title defence.
Even under Ferguson, United had gone through their fair share of struggles, but for the most part always maintained an approach of solidarity among players and coaching staff alike.
Therefore, it's a rare occasion hearing such a senior squad figure speak so candidly about any doubts he may have regarding the new management barely seven months into the job.
Ferdinand, 35, has played in just seven of his side's 14 Premier League games this season, with Jonny Evans, Nemanja Vidic, Chris Smalling and Phil Jones all rotating in central defence.
The defender's current deal with the club will expire in the summer of 2014 and it remains unclear as to whether another one-year extension will be put into effect.
The Red Devils have managed just three clean sheets this term and Ferdinand's comments will undoubtedly be looked upon as another stark contrast between how things have been run at the club now compared to how they were with Moyes' predecessor.
The manager isn't the only one adapting to change, however, and one might argue that it's as much the players' responsibility in accommodating the coach as he looks to employ his policies.
In any case, this would appear to be one aspect of Moyes' reign that doesn't sit altogether comfortably with one of Manchester United's longest-serving charges.