The pace of the Premier League is unrelenting this week, and another batch of fixtures is upon us after a full midweek programme.
Manchester United will be looking to bounce back from a home defeat by Everton when Newcastle visit on Saturday.
The game of the weekend takes place Sunday at the Emirates Stadium, where league leaders Arsenal will take on in-form Everton.
But who will be available this weekend and who won't?
Manchester United vs. Newcastle
Manchester United manager David Moyes will be hoping striker Robin van Persie will be available again, but midfielder Michael Carrick remains sidelined with a calf problem. Wayne Rooney is suspended, but Phil Jones returns after a ban. Shinji Kagawa has been ill this week and will be assessed before the game.
Newcastle striker Papiss Cisse is doubtful with a heel problem, while defender Ryan Taylor is a long-term absentee. Hatem Ben Arfa is expected to return.
Crystal Palace vs. Cardiff City
Crystal Palace manager Tony Pulis is hoping to welcome back midfielder Jerome Thomas from a foot injury, while defender Patrick McCarthy could also return. Yannick Bolasie serves the last match of a three-game suspension.
Cardiff City have no injury concerns ahead of the trip to Selhurst Park after Craig Bellamy and Andrew Taylor returned to the squad.
Liverpool vs. West Ham United
Liverpool will be without long-term casualties Daniel Sturridge, Jose Enrique and Sebastian Coates for the visit of West Ham.
The Hammers have no fresh injury concerns, although Andy Carroll, Ricardo Vaz Te, Alou Diarra and Winston Reid remain sidelined. Ravel Morrison is banned for one game.
Southampton vs. Manchester City
Gaston Ramirez returns after a cold, Victor Wanyama, Nathaniel Clyne and Morgan Schneiderlin are out, while Jose Fonte is a doubt.
Vincent Kompany is set to return for Manchester City, but Matija Nastasic is still absent. David Silva and Stevan Jovetic are approaching returns to action.
Stoke City vs. Chelsea
Stoke City defender Robert Huth is the only confirmed absentee, due to a knee injury.
Oscar and Samuel Eto'o should be available again for Chelsea, but defender David Luiz is likely to be out for a little longer with a knee problem.
West Bromwich Albion vs. Norwich City
West Brom could welcome back Nicolas Anelka and Scott Sinclair, but Ben Foster could be back next week. Defender Jonas Olsson is suspended for one game.
Norwich manager Chris Hughton still has injury concerns, with Anthony Pilkington, Robert Snodgrass, Mark Bunn and Alex Tettey all still absent. Striker Ricky van Wolfswinkel is still doubtful.
Sunderland vs. Tottenham Hotspur
Sunderland defender Carlos Cuellar and goalkeeper Kieren Westwood are the only injury absences for Gus Poyet.
Tottenham manager Andre Villas-Boas will be hoping Mousa Dembele will return, but Christian Eriksen, Emmanuel Adebayor and Jan Vertonghen remain on the treatment table.
Fulham vs. Aston Villa
Brede Hangeland could return for Fulham, but Hugo Rodallega is still sidelined.
Aston Villa manager Paul Lambert will be hoping to welcome back Joe Bennett after a back problem, but Charles N'Zogbia remains sidelined.
Arsenal vs. Everton
Arsenal manager Arsene Wenger will be monitoring the fitness of striker Lukas Podolski, who could return, but defender Bacary Sagna is still sidelined.
Everton have no fresh injury concerns, but Leighton Baines, Arouna Kone and Darron Gibson remain sidelined.
Swansea City vs. Hull City
Swansea manager Michael Laudrup is waiting on news of Michu's availability after injury, but Angel Rangel and Wilfried Bony are still out.
Hull defender Paul McShane could be set for a return to action, but Sone Aluko will be out until the end of January.