So far, Everton has been surprisingly good, as the Toffees have lost just one match in league play, and there's reason to believe this club's got what it takes to earn a Champions League berth by season's end.
At the other end of the pitch, David Moyes will be looking to secure a victory in his first showdown against his former club.
More importantly, Moyes and company need to put forth a good effort in order to erase the disappointment of last weekend's draw on the road against Tottenham.
Heading into what should be one of the week's most intriguing tilts, here's a look at everything you need to know in order to catch all the action from Old Trafford.
When: Wednesday, Dec. 4, at 2:45 p.m. ET; 7:45 p.m. GMT
Where: Old Trafford, Manchester
Watch: NBC Sports Network
Live Stream: NBC Sports Live Extra
Odds (via Sky Bet): Manchester United (8-11), Everton (7-2), Draw (11-4)
Who will win?
Top Storyline: Will the Red Devils Have Robin van Persie on the pitch?
As arguably the game's most dangerous striker, Robin van Persie's presence alone obviously makes Moyes' offense considerably more dangerous.
Yes, Manchester United has managed to pile up nine goals in the three matches since the Dutch star was shelved following the victory over Arsenal, but as the team's top offensive weapon, van Persie's return would be very much welcomed.
So far, RVP has seven goals in nine starts this season, and even with Wayne Rooney firing on all cylinders, the former Arsenal sniper is the centerpiece of this attack.
Even if he's not at full strength, van Persie adds another dimension up front, as his ability to get a foot or head on the ball in clutch situations is often a deciding factor in his club's matches.
It's worth noting that Rooney's stepped up in his co-star's absence, but there's reason to believe the outcome of this match will be significantly different in van Persie's on the field.
Prediction: Manchester United 2, Everton 1
Everton has only lost one match thus far, which was a 3-1 defeat against Manchester City, but United has looked like a squad on a mission after stumbling early on.
Despite van Persie's absence, Moyes' bunch has found ways to create offensive chances, as Wayne Rooney has racked up three goals in his last two matches and has eight in league play to date.
One X-factor for the Blues will be Romelu Lukaku, who has eight tallies of his own while on loan from Chelsea.
However, Manchester United will certainly be motivated and engaged against a quality opponent, and as we saw against Arsenal, that's not good news for the visiting side.
It won't be easy, but Rooney and van Persie (assuming he's available) will lead United to the club's sixth straight victory at Old Trafford.