Stylistically, this match presents an intriguing battle between the approach of both managers.
Roberto Martinez has instructed his side to retain possession and control games as much as possible this season, while Manchester United have become something of a counter-attacking side without Robin van Persie.
That considered, it seems unlikely either side will remain completely committed to their recent philosophy.
Without Van Persie, Manchester United have been compact in the middle and had pace in their four most attacking positions, occupied by the likes of Wayne Rooney, Shinji Kagawa, Antonio Valencia, Nani and Danny Welbeck.
This has enabled them to launch some electric breaks that have proved effective away at Tottenham and especially against Bayer Leverkusen.
However, at home the Red Devils will want more of the ball and Martinez's Everton will perhaps be more content to drop a little deeper and launch their own counter-attacks through the pace of Kevin Mirallas, Gerard Deulofeu, Ross Barkley and Romelu Lukaku.
How each manager opts to go will prove fascinating viewing. Martinez's tactics shone through during their last encounter, as his Wigan side won 3-0 at Everton in the FA Cup quarter-final.
Statistics via WhoScored?