Saturday, Nov. 30, at noon ET (ABC)
Every year this game matters—forget the records, forget what "Ohio" is doing nationally and what "That School Up North" isn't doing nationally. These two programs, these two schools and these two states flat out hate each other.
That said, this game is perhaps the biggest mismatch we've seen on paper in quite some time.
Ohio State features the third best scoring offense and the eighth best scoring defense in the country. It scores 48.7 points a game and gives up just 18.4 points a game.
Even more than that, Ohio State features perhaps the most potent run game Urban Meyer has ever had. Running back Carlos Hyde leads the Big Ten in rushing during conference play with 1,023 yards and has 1,064 yards this season.
Quarterback Braxton Miller has come on recently in the run game as well, rushing for 184 and 144 yards in the last two weeks. He has 738 yards on the year to go with five rushing touchdowns.
Those two will face a rushing defense that has given up just 116.4 yards a game and nine touchdowns.
Something will have to give and the biggest advantage goes to Ohio State up front. The Buckeyes feature the Big Ten's best offensive line unit and that, more than anything Hyde or Miller has done, has been the biggest help to the run game this season.
Defensively, Ohio State has really grown on the line this year and a lot of it has to do with freshman Joey Bosa and his growth. He has become more aggressive and a bigger playmaker for his team and the rest of the defensive line has also followed suit.
Ohio State leads the Big Ten in sacks during conference games (27) and overall (36). The defense also has — tackles for loss on the season.
That's not good news for a Wolverines offensive line that has helped lead this team to a dead last ranking in tackles for loss allowed nationally (9.36 a game) and rank 110th nationally in pass sacks given up.
More than anything Ohio State's offense can or will do Saturday in Ann Arbor, it's the defense that will win this game for the Buckeyes.
The Wolverines simply haven't shown anything in the run game and if you can't run against the Buckeyes, you aren't winning the game.
Look for Hyde to go for more than 150 yards and two touchdowns and Miller to rush for more than 100 yards himself as Ohio State puts a beating on "That School Up North."
Prediction: Ohio State 45, Michigan 17
Andy Coppens is Bleacher Report's lead writer for the Big Ten. Odds courtesy VegasInsider.com. Rankings are official BCS rankings. Don't forget to follow Andy on Twitter: @ andycoppens.