South Carolina enters this matchup between top 10 teams riding a four-game winning streak against the Tigers.
This is the 111th renewal of the series, and a victory would give the Gamecocks an unprecedented fifth consecutive triumph over their archrival.
The game is critical to Clemson, not only to avoid the stigma of losing five straight to its rival, but also because the Tigers have an outside shot of playing in the national championship game.
That shot only remains if the Tigers can beat the Gamecocks.
What: No. 6 Clemson (10-1) vs. No. 10 South Carolina (9-2)
When: 7 p.m. Saturday
Where: Williams-Brice Stadium, Columbia, S.C.
Series: Clemson leads 65-41-4