There is little margin for error for Europe's elite as the next round of Champions League fixtures arrives this week.
Manchester United, Arsenal, Chelsea and Celtic are still fighting for a place in the knockout rounds, while Manchester City are gunning for top spot against Bayern Munich in Group D.
Let's take a look at the full schedule, kick-off times and television listings before focusing on Premier League interest in the competition.
|Champions League Matchday 5|
|Group||Fixture||Date, K/O Time and Location||Broadcaster|
|E||Basel vs. Chelsea||Nov. 26, 7:45 p.m. GMT, St. Jakob Park.||Sky Sports 2 HD|
|E||Steaua Bucharest vs. Schalke 04||Nov. 26, 7:45 p.m. GMT, National Arena.||Sky Sports Red Button|
|F||Arsenal vs. Marseille||Nov. 26, 7:45 p.m. GMT, Emirates Stadium.||ITV 1 HD|
|F||Borussia Dortmund vs. Napoli||Nov. 26, 7:45 p.m. GMT, Westfalenstadion.||Sky Sports Red Button|
|G||Zenit St. Petersburg vs. Atletico Madrid||Nov. 26, 5 p.m. GMT, Petrovsky Stadium.||Sky Sports 2 HD|
|G||Porto vs. Austria Vienna||Nov. 26, 7:45 p.m. GMT, Estadio do Dragao.||Sky Sports Red Button|
|H||Ajax vs. Barcelona||Nov. 26, 7:45 p.m. GMT, Amsterdam Arena.||Sky Sports Red Button|
|H||Celtic vs. AC Milan||Nov. 26, 7:45 p.m. GMT, Celtic Park.||Sky Sports 4 HD|
|A||Bayer Leverkusen vs. Manchester United||Nov. 27, 7:45 p.m. GMT, BayArena.||Sky Sports 2 HD|
|A||Shakhtar Donetsk vs. Real Sociedad||Nov. 27, 7:45 p.m. GMT, Donbass Arena.||Sky Sports Red Button|
|B||Juventus vs. FC Copenhagen||Nov. 27, 7:45 p.m. GMT, Juventus Stadium.||Sky Sports Red Button|
|B||Real Madrid vs. Galatasaray||Nov. 27, 7:45 p.m. GMT, Bernabeu.||Sky Sports Red Button|
|C||Paris Saint-Germain vs. Olympiakos||Nov. 27, 7:45 p.m. GMT, Parc des Princes.||Sky Sports Red Button|
|C||Anderlecht vs. Benfica||Nov. 27, 7:45 p.m. GMT, Constant Vanden Stock Stadium.||Sky Sports Red Button|
|D||CSKA Moscow vs. Bayern Munich||Nov. 27, 5 p.m. GMT, CSKA Moscow Stadium.||Sky Sports 4 HD|
|D||Manchester City vs. Viktoria Plzen||Nov. 27, 7:45 p.m. GMT, Etihad Stadium.||Sky Sports 4 HD|
|Fixtures via BBC Sport|
UK viewers can watch Sky Sports’ live games on the Sky Player website or via Sky Go for laptops and mobile devices (subscription required). Live scores are also provided on Sky Sports News throughout each match, while highlights are also shown throughout both nights on various Sky Sports channels.
Highlights of the first day's action can also be found on ITV 1 at 10:35 p.m. GMT on Tuesday. Be sure to check LiveonSat for your local listings and stream information.
Basel vs. Chelsea
Chelsea have responded excellently since losing to Basel during the opening round of Champions League matches.
Jose Mourinho's men went down 2-1 at Stamford Bridge back in September, but a 4-0 thrashing of Steaua Bucharest and back-to-back wins over Schalke see the English side take control of Group E.
The Blues will qualify for the knockout stages if they avoid defeat in Switzerland, but there's no doubt Mourinho should be looking to take all three points.
Victory confirms Chelsea as group winners, providing the 2012 winners with plenty of motivation as they hop on the plane.
Should Chelsea serve up a dose of revenge against Murat Yakin's side, Basel will need Bucharest to take points off Schalke if they are to fight for second place on the final day.
Arsenal vs. Marseille
Arsenal's victory over Borussia Dortmund is likely to be the pivotal result in Group F.
Arsene Wenger's team is now three points ahead of the Bundesliga team and top the group on nine points, ahead of Napoli by virtue of the win over the Italians on home soil.
While the Gunners' fiercest rivals duke it out at the Westfalenstadion, Arsenal have the perfect opportunity to take a giant leap toward qualification against a Marseille side that are yet to register a point in this year's Champions League.
Should Arsenal grab victory and Dortmund fail to beat their Serie A visitors, qualification is sealed. The trip to Naples is likely to be tricky either way, especially if Wenger wishes to grab top spot in the group.
Bayer Leverkusen vs. Manchester United
Bayer Leverkusen were played off the park when they lost 4-2 against Manchester United at Old Trafford. The Red Devils put in a lethal performance which arguably ranks as the best display under David Moyes to date.
Even so, the Germans will be more than confident of beating the Premier League champions. United are yet to win away in European competition this campaign, as disappointing draws against Shakhtar Donetsk and Real Sociedad threaten to prove fatal.
United are unbeaten in 10 games across all competitions and currently reside one point clear of Leverkusen at the top of Group A.
With Shakhtar lurking just three points behind the leaders, this group is still for the taking.
Priority: Topping the Group
Manchester City vs. Viktoria Plzen
Manuel Pellegrini has turned Manchester City's European form around and already guided the Sky Blues toward a knockout place.
They must win to keep pressure up on Bayern Munich, who currently lead the group by three points. A failure to do so, combined with a Bayern win, will see City confirm second place and a tougher draw in the next round.
Should City maintain their excellent home form against Plzen, another victory will be needed at the Allianz Arena to oust Bayern from the top.
With Joe Hart set to return in goal, reported by BBC Sport, there still remains much to play for in this encounter.