Mathews proved his worth as a feature back in San Diego's offense in the 20-16 loss, carrying the ball 19 times for 127 yards en route to nearly seven yards per carry.
He ripped off a 51-yard scamper late in the third quarter for his team's biggest offensive gain of the day.
The fourth-year back has consistently received a big workload in the Chargers backfield, but he has been hot and cold as far as production goes. He also hasn't surpassed 17 ESPN fantasy points in a game all season.
The Chargers have lost three straight, but Mathews is only getting better despite his team's recent struggles. Even in losses, the traditionally pass-happy Chargers offense is getting Mathews involved early and often.
Mathews is only started in 30 percent of ESPN leagues, but that should rise with his continued improvement.
Considering the running back's recent form, Mathews is a reliable RB2 or flex option in most standard leagues. If you had any doubts about that prior to Week 11, his big game should serve as proof that he can carry the load.