Saturday, November 23, 3 p.m. GMT at Emirates Stadium
(Current league position: 1st vs. 3rd)
Few would have predicted a clash between Arsenal and Southampton in late November would be first against third in the Premier League, but that's exactly what this is.
Arsenal have been on fire since the arrival of Mesut Ozil, while Southampton have used their incredible defense to rise up the league ladder. They come into this fixture with just five goals against in 11 matches.
Arsenal have won their last four home fixtures at the Emirates and will certainly fancy their chances at toppling the Saints here, but don't be surprised to see Mauricio Pochettino's men prove tougher than first thought.
Southampton provide great pressure from their central defenders and should eliminate much of the space in which Olivier Giroud thrives, forcing them to look out wider to the likes of Santi Cazorla, Theo Walcott and Bacary Sagna to try and break down the defense.
In turn, that could leave them a touch exposed on the counter-attack (particularly if Aaron Ramsey is lined up in defensive midfield) with Southampton holding plenty of threats of their own in Rickie Lambert, Adam Lallana and 19-year-old sensation James Ward-Prowse.
Call me crazy, but I'm going for the upset here. Southampton's defense is the real deal, while Arsenal's has had question marks around it all season, even with only 10 goals against.
Of course, it'll take a bit of luck, but the Saints have had this this fixture circled on the calendar for a long time and will no doubt be up for it. If they can go undefeated away to Stoke City, Manchester United and Liverpool, there's nothing to suggest that they can't do the same against the league leaders this weekend.
Prediction: Arsenal 0-1 Southampton