The duo were surprise call-ups to Roy Hodgson's squad last week and look set to be given the chance to impress in what will be a highly experimental lineup.
Southampton duo Jay Rodriguez and Adam Lallana will be given their England debuts against Chile at Wembley tonight.
Forward Rodriguez and midfielder Lallana are understood to have been told by Roy Hodgson that they are in the starting line-up.
England boss Hodgson held a team meeting today and they have got the nod. James Milner, Jack Wilshere and Frank Lampard are also set to start against Chile.
With Liverpool's Daniel Sturridge an injury doubt for the game, per the Guardian's Andy Hunter, and Cross reporting that Rickie Lambert joins both Sturridge and Welbeck on the absentee list, Rodriguez is left to lead the line for England alongside Wayne Rooney or Jermain Defoe.
It was confirmed by the FA on Thursday that Lampard, who recently reached 100 caps for his country, will captain the side on Friday evening.
Hodgson is clearly evaluating some options ahead of the World Cup against Chile, with a first-choice available lineup expected to take on Germany in midweek.
However, the England manager would be wrong to assume Chile will not be a challenge, with Jorge Sampaoli's side having lost just one of 12 fixtures this calendar year.
Chile are set for next summer's World Cup and, with the dangerous Alexis Sanchez and Eduardo Vargas in forward roles, will test England on the counter-attack.
England will be tested fully on Friday and Hodgson will learn a lot about the fringe names he is considering for a World Cup spot next summer.