Uruguay have one foot in the World Cup finals after crushing Jordan 5-0.
A close-range tap-in from Maxi Pereira in the 22nd minute gave the South Americans an early lead in their play-off first leg in Amman.
They doubled their advantage 20 minutes later, via Christian Stuani.
Oscar Tabarez' men virtually sealed their place in next year's finals in Brazil with three second-half goals. Nicolas Lodeiro made it 3-0 on 70 minutes with a crisp strike.
Cristian Rodriguez then put some extra gloss on the scoreline seven minutes later.
Edinson Cavani saved the best until last with a glorious fifth from a free-kick.
The scoreline makes Wednesday's second leg in Montevideo little more than academic.