England captain Steven Gerrard and the 2012 PFA Young Player of the Year Kyle Walker have both been ruled out of contention to face Chile in Friday's international friendly.
From BBC Sport via Twitter:
Having already lost Danny Welbeck and Michael Carrick to injury, Roy Hodgson's plans have suffered a further setback following another two key withdrawals, although the upheaval should offer up a chance to bring fresh blood into the team.
Southampton's Adam Lallana and Jay Rodriguez are already in the squad to face Chile and could find their chances of making full international debuts boosted by England's latest selection headaches.
There may be another high-profile absentee announced too if the following tweet by The Daily Telegraph's Henry Winter snowballs into Frank Lampard's withdrawal:
Walker/Gerrard out of #eng game v Chile. Lampard 'under the weather' (but he is training)— Henry Winter (@henrywinter) November 13, 2013
Should Lampard's "under the weather" condition be connected in any way to the stomach bug at the FA's St. George's Park facility—reported by BBC Sport—other complaints may yet follow.
However, with Liverpool's Jordan Henderson and Everton's Ross Barkley already in the squad, Hodgson has announced he will not be looking to bring in any replacements, per ESPN.
Henderson has been one of the league's form midfielders this season if the superlative-ridden run of Welshman Aaron Ramsey is discounted as an outlier.
His Merseyside rival Barkley will be hoping he too can find opportunities to make his case for a role at the World Cup in Brazil next summer.
If Hodgson was to change his mind and call up a player to reinforce his starting XI, the obvious choice would be Gareth Barry, who has been another midfielder to have impressed so far this season for Everton.
His maturity as the Toffees' main holding player has allowed Barkley to play a more aggressive and risky game in the final third, and with both Gerrard and Lampard potentially out of action, their combination could be useful.
Meanwhile, Glen Johnson is the likely candidate to step in for Walker as the team's attacking full-back down the right.
The versatility of Phil Jones and Chris Smalling also gives Hodgson the option of a more conservative presence on that flank should he believe Alexis Sanchez's roaming attacks need to be countered by his team selection at Wembley.