The Rams walked away with a lopsided 38-8 victory, embarrassing the Colts in front of their home crowd.
Tavon Austin was easily the major story of this game.
It was nine months ago that the rookie receiver shocked the league with a monster performance at Lucas Oil Stadium during the NFL combine, which secured his status as a top-10 draft pick, so it's only appropriate that his return to Indianapolis results in another career milestone.
The lightning-fast rookie produced 138 receiving yards on two catches and broke free for a third touchdown as a punt returner.
The St. Louis defense had a dominant game as well, recording three sacks, four picks and one fumble recovery for a touchdown.
The Rams defense held the Colts to minus-three rushing yards in the first half and only 20 rushing yards total. They did allow Luck to pass for 353 yards, but many of those yards came after the game was out of hand.
Every aspect of this game worked in St. Louis' favor, resulting in its best performance of the 2013 season.
The Rams will now enter the bye week as they prepare for a home game against the tough Chicago Bears.
In the meantime, here are my takeaways from St. Louis' thumping of the Colts.