With injuries and bye weeks serving as major obstacles for fantasy football owners once again in Week 10, many will be forced to take a gamble this weekend.
Whether it's an unproven quarterback with upside or a backup who's beginning to emerge as a productive player, you've got to take risks in order to win it all.
With kickoff fast approaching, here's some last-minute advice on how to handle notable fringe performers in Week 10.
*Availability and scoring statistics according to ESPN Fantasy.
|Start 'Em, Sit 'Em Week 10|
|Player||Average Points||Week 10 Opponent||Fantasy Play|
|Jake Locker, Titans||11.9||Jaguars||Start|
|Christian Ponder, Vikings||8.8||Redskins||Start|
|Ryan Mathews, Chargers||7.6||Broncos||Start|
|Hakeem Nicks, Giants||6.3||Raiders||Start|
|Greg Jennings, Vikings||6.0||Redskins||Start|
|Rashad Jennings, Raiders||5.4||Giants||Start|
|Garrett Graham, Texans||4.9||Cardinals||Start|
|Donald Brown, Colts||4.1||Rams||Start|
|Terrelle Pryor, Raiders||13.5||Giants||Sit|
|Ryan Tannehill, Dolphins||12.6||Buccaneers||Sit|
|Joique Bell, Lions||8.6||Bears||Sit|
|Cecil Shorts, Jaguars||7.6||Titans||Sit|
|Harry Douglas, Falcons||7.1||Seahawks||Sit|
|Brian Hartline, Dolphins||6.9||Buccaneers||Sit|
|Ray Rice, Ravens||5.8||Bengals||Sit|
Garrett Graham, Houston Texans, TE
Own Percentage: 24.2
Average Points: 4.9
Week 10 Opponent: Arizona Cardinals
Houston Texans tight end Garrett Graham has been flying under the radar over the past four games. After catching three touchdowns through the first four weeks of the season, Graham has been in a serious scoring drought.
But expect that to end this weekend.
Rookie quarterback Case Keenum has targeted Graham 14 times over the past two games, and the duo will have an incredibly favorable matchup in Week 10. The Arizona Cardinals have had no answer for opposing tight ends in 2013 and are the only team in the league surrendering more than 10 fantasy points per week to opposing tight ends, per ESPN Fantasy.
Therefore, if Graham is going to end his touchdown drought this year, he's likely to do so on Sunday.
Fantasy Play: Start
Brian Hartline, Miami Dolphins, WR
Own Percentage: 41.6
Average Points: 6.9
Week 10 Opponent: Tampa Bay Buccaneers
While Dolphins quarterback Ryan Tannehill has been targeting wide receiver Brian Hartline on a consistent basis this season, the veteran has been unable to make much of an impact for fantasy owners.
Hartline hasn't caught a touchdown since Week 3 and has racked up more than 60 receiving yards just twice since Week 1's stellar performance at Cleveland. And in Week 10, Hartline and the Dolphins will be up against a decent secondary in Tampa Bay.
The Bucs rank 15th in fewest passing yards allowed and should be able to limit Hartline's downfield production on Monday night, making him better suited for the bench on Sunday.
Fantasy Play: Sit
Donald Brown, Indianapolis Colts, RB
Own Percentage: 6.5
Average Points: 4.1
Week 10 Opponent: St. Louis Rams
The fact that Donald Brown is averaging 6.3 yards per carry this season is all fantasy owners need to know heading into the Colts' Week 10 showdown with the St. Louis Rams.
While Brown hasn't carried the ball more than 11 times in a game this year, Trent Richardson's struggles (3.0 yards per carry since being traded from Cleveland) have opened the door for more attempts for the veteran, who can also make an impact as a receiver in the passing game.
More importantly, Brown and the Colts will be up against one of the league's worst run defenses this weekend. St. Louis is surrendering more than 125 yards per game on the ground, and only three teams have allowed more rushing touchdowns than the Rams through nine weeks.
Fantasy Play: Start
Follow Bleacher Report Featured Columnist Patrick Clarke on Twitter.