With Arsene Wenger's team top of the table by five points—eight points ahead of United who lie in eighth position—it looks as though one of English football's grandest competitive rivalries is set to be reignited, and in some style.
Although the Gunners may have already triumphed in pivotal games away to Jurgen Klopp's Borussia Dortmund and at home against Liverpool, a result at the Theatre of Dreams would confirm the early leaders' credentials as legitimate front runners for the title.
However, should David Moyes' much maligned team flip all expectations and halt Arsenal's advance, those who suggested that their comeback win against Stoke City in October would prove to be a turning point for United's season could be vindicated in the most dramatic of fashions.
Much will come down to what team Moyes selects over whether their mini-resurgence—United are currently on an eight-match unbeaten run in all competitions—can be sustained.
While Arsenal's gap at the top has lead to talk of the Gunners heading to Old Trafford with zero pressure to perform and nothing to lose, Wenger himself has cited the game as a vital "benchmark" according to Sky Sports.
We're still within touching distance and to get a victory on Sunday will put us in a great position I think. It is the perfect fixture for us. Arsenal are obviously doing really well but with our current form, it is a chance for us to get a bit closer in the table.
The pressure will be on both teams to prove their value to the title race, with question marks lingering over Arsenal's ability to hold their nerve for a full season and United's competitiveness in the post-Ferguson era.
As a result, viewers of the Premier League could well be in for a treat as both these two storied clubs collide once more to test their mettle and their quality.