After trailing by four points at halftime, the Miami Heat (4-2) would go on to outscore the Los Angeles Clippers (3-) 50-41 in the final 24 minutes, eventually winning the game by a final score of 102-97.
Dwyane Wade led all scorers with 29 points on an efficient 13-of-22 from the field. He also chipped in seven assists, four rebounds and three steals.
LeBron James, who was relatively quiet in the opening two quarters, became more assertive in the second half, ending the night with 18 points, six assists and five rebounds.
Chris Bosh, who was playing for the first time since the birth of his child, finished with 12 points in 29 minutes.
The Heat as a team shot 53.5 percent from the field, including a scorching 60.0 percent in the first half. They also set a franchise-record by scoring over 100 points for the sixth-straight game to start a season.
The Los Angeles Clippers were led by Blake Griffin, who finished with a double-double of 27 points and 14 rebounds. His slam dunk with 31 seconds remaining in the game brought his team to within four points, but not fouling James and allowing 15 seconds to come off the clock helped seal their fate.
DeAndre Jordan also had a double-double in his own right of 11 points and 14 rebounds.
Chris Paul was kept in check on offense by the Heat's swarming defense, hitting just 3-of-11 from the field and turning the ball over five times. He did however contribute 12 assists.
Miami will host the visiting Boston Celtics on Saturday night, while the Clippers will look to end their two-game losing streak with a win in Houston against the Rockets in two days as well.
FINAL SCORE: Miami Heat 102, Los Angeles Clippers 97