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First up is a daunting trip to the BVB Stadion Dortmund to take on last season's UEFA Champions League runners-up, Borussia Dortmund.
When the two teams last met, Dortmund ran out convincing 2-1 winners. That victory was at the Emirates Stadium on October 22 and threatened to burst the bubble of optimism and hope that was dawning on the Gunners.
Arsenal, however, bounced back from that little blip in the best of fashions and easily beat Liverpool 2-0 to go five points clear at the top of the Premier League.
They now face one of the toughest, if not the toughest, matches of their entire season. Mikel Arteta summed the game up perfectly to Sky Sports when he said: "The Dortmund game is huge. We don't want to go to Napoli needing a win."
Dortmund, under the charismatic and heavy metal-loving Jurgen Klopp, are one of the best footballing sides in the world. They are exciting to watch and possess danger players in every section of the team.
Marco Reus is the undoubted jewel in Dortmund's crown and he is the man that Arsene Wenger will have to be most wary of.
The two managers share a great respect of each other and in the pre-match press conference, covered by Sky Sports, Klopp showed his great admiration for Wenger while comparing the two teams in the most unusual of ways.
He is really something. I love him. He is Sir Arsene Wenger.
But he likes having the ball, playing football, passes... It's like an orchestra. But it is a silent song. I like heavy metal more. I always want it loud.
When I watch Arsenal in the last ten years it is nearly perfect football but we all know they didn't win a title.
Who wins the title? Chelsea, but with different football. But this is the philosophy of Wenger. I love this but I cannot coach this as I am different.
I love it when I read after the game that we ran more than the opponent. If somebody tells me after the game that we ran 10km more than the opponent, that's good.
I want to fight with perfect defense, switching to offense, very fast, switching back to defense very fast.
What I love, I do with all I have. I fight for justice. It's a very important point for me. You give all... there's no guarantee that you get all but if you give all maybe you can get something.
Fighting football, not serenity football, that is what I like.
No doubt about it, Arsenal face a very stiff test in Dortmund.
Borussia Dortmund (Home)—Arsenal (Away)
Tackles per game: 27—18
Shots per game: 25—13