Brendan Rodgers' side will go above the Gunners in the table with a victory at the Emirates Stadium, and they'll enter the game full of confidence following last weekend's 4-1 victory over West Bromwich Albion, surely their best display of the season so far.
Luis Suarez's hat-trick and Daniel Sturridge's deft chip earned the Reds that impressive win at Anfield, but with Arsenal unbeaten in the league since the opening day, the likes of Mesut Ozil, Santi Cazorla and Olivier Giroud are likely to present a tougher challenge.
How does Rodgers play it then? And how will Liverpool's three-man defence work against one of the most vibrant sides in the league?
Here's how the Reds are likely to line up on Saturday evening.