At college football's highest level, teams with the most depth and talent have the most breathing room when it comes to swapping out players who aren't performing.
And while the outcome of every game becomes more and more crucial as the season enters its closing stretch, that margin for error will only shrink.
That could happen with several quarterbacks in the Big 12, including at Iowa State and even in the pass-happy Oklahoma State offense.
Meanwhile, injury may have put two other quarterbacks on the hot seat, one in the Big 12 and the other in the Big Ten.
Finally, two All-American caliber running backs could see their snaps reduced thanks to injury.