Right from the start, the game was filled with many emotions, as Indianapolis fans gave a warm standing ovation for Peyton Manning on his homecoming night.
However, it was really Andrew Luck who became the star of the show as he led the Colts to a 39-33 victory and put an end to the Broncos' undefeated streak.
The game had many exciting moments, drama and even some controversy. Naturally, many watching the game took to Twitter to express their reactions.
Here are the best Twitter reactions from the Denver Broncos' Week 7 loss.
Many of the tweets raved about Andrew Luck's performance, as he threw for three TD passes and ran another for a TD. As a result, the overused "Luck" pun was in full effect on Twitter, notably used by Terrell Owens.
The young QB has won the hearts of Indianapolis fans and may have finally stepped out of Manning's shadow.
Or maybe not.
Luck's football abilities weren't the only thing being praised. After a controversial penalty, due to what may have been a flop by Luck, tweets began to endorse Luck's NBA career.
Surprisingly, the biggest highlight of the game did not come Manning or Luck. It came from Colts punter Pat McAfee, who laid out Trindon Holliday, restoring the manhood of kickers everywhere. Apparently Twitter experienced some problems due to the overload of reactions to McAfee's big hit.
Skip Bayless also had some comments.
The Colts' victory came as a surprise to many in the sports world and forced even the most opinionated media members to acknowledge their errors.
Sportscaster Charissa Thompson was very adamant that Peyton Manning was going to win the game.
However, after the Broncos lost, she admitted her defeat.
Jim Irsay had been very vocal in the last week and stirred up drama in the newspaper before the match, so when his Colts won the game, of course he took to Twitter to voice his thoughts. He had a word or two for his haters.
In a postgame interview, Colts cornerback Vontae Davis was confused about which quarterback his team had just faced and told the reporter that they prepared really hard for Tom Brady. Twitter had a good laugh at Davis and posted a few wonderfully sarcastic tweets.
Davis was a good sport about it though, and laughed the situation off on Twitter.
While the Broncos' undefeated streak has ended, it was not a typical performance from Denver. Manning lost a fumble, threw a interception and was sacked four times. To make matters worse, Trindon Holliday also fumbled the ball twice. Do not expect that to happen again in the season.
Even with this loss, the Broncos are still one of the elite teams in the league. However, they fall to second place in the AFC West to the Kansas City Chiefs, who are now the only team without a loss. It is safe to say no one expected the Chiefs to be undefeated after week 7.