Denver had nearly 100 yards more of total offense, but it was two turnovers that proved costly.
The Broncos (6-1) will head back home to face the Washington Redskins in Week 8.
Broncos - 33
Colts - 39
Passing Offense: Peyton Manning threw for 386 yards but only completed 29 of the 49 passes he attempted. The offensive line struggled all night in keeping Manning away from the Colts' pressure.
Passing Defense: The Broncos held Andrew Luck to just 228 passing yards, but he was able to make the big plays when he had to.
Rushing Offense: Denver ran for just 64 yards on the night, but it was a curious call late in the game that buried them. Trailing 39-30 with the ball on the Indianapolis 2-yard line, Ronnie Hillman, who has been plagued by fumbles, was given a carry and lost the ball.
Rushing Defense: The Broncos did a good job bottling up the Colts' rushing attack, but it was the feet of Luck that really hurt them. He gained 29 yards and scored a touchdown running.
Special Teams: Broncos punter Britton Colquitt had kicked the ball just 18 times through six games this season. He had to punt the ball seven times Sunday night.
Coaching: The coaching staff was obviously looking to get the very quick Hillman into the game to help the offense become even faster, but his ball security issues continue to be a major problem.
Passing Offense: Manning has completed just nine passes in the first half as the Colts have done a good job of hurrying his throws. Still, Manning managed to post two touchdown passes in the first half to give him 24 on the season.
Passing Defense: Indianapolis quarterback Andrew Luck is having an excellent game, throwing for 199 yards and three touchdowns in the first half. Denver must do a better job of covering the flat. Two of the Colts' touchdowns came on short passes to the flat that Denver was in no position to defend.
Rushing Offense: There hasn't been much room for the Broncos to run the ball in this game. Knowshon Moreno was held to just 34 yards in the first half and was stuffed for short gains on most of his 11 carries.
Rushing Defense: Indianapolis has shown a desire to run the ball and control time of possession. Denver has done a good job defending by giving up just 48 yards rushing in the first half.
Special Teams: Trindon Holliday has brought multiple kickoffs from deep out of his own end zone, and on one of those, he was stripped of the ball. That gave the Colts the ball at the Denver 11-yard line.
Coaching: Denver needs to keep things in perspective and not panic. The Broncos moved the ball well, but they must do a better job protecting Manning, even with their makeshift offensive line. The pressure Indianapolis has been able to put on Manning is a key to this game.