Dos Santos knocked Velasquez out in the first round of their initial meeting. Velasquez dominated JDS from start to finish in their second clash. Clearly the two best heavyweights in the world, the winner of Saturday's bout could have a lengthy title run ahead.
In addition to the heavyweight championship bout, UFC 166 could produce top contenders in the light heavyweight and lightweight divisions.
Though fighting at heavyweight on Saturday, Daniel Cormier is expected to move to 205 pounds in his next outing. An impressive win over Roy Nelson at UFC 166 could position Cormier for a quick shot at the light heavyweight strap.
On the heels of a controversial loss to then-champion Benson Henderson, Gilbert Melendez will try to jump back into the title hunt Saturday. Standing between the former Strikeforce champion and another shot at the belt will be fellow former title challenger Diego Sanchez.
Here is how MMA fans can tune in to watch every portion of the UFC 166 fight card.
Online Prelims: 6 p.m. ET
- TJ Waldburger vs. Adlan Amagov
- Tony Ferguson vs. Mike Rio
- Jeremy Larsen vs. Andre Fili
- Dustin Pague vs. Kyoji Horiguchi
Online prelims will be shown on UFC.com.
Fox Sports 1 Prelims: 8 p.m. ET
- Tim Boetsch vs. CB Dollaway
- Nate Marquardt vs. Hector Lombard
- Sarah Kaufman vs. Jessica Eye
- George Sotiropoulos vs. KJ Noons
To find out how to watch Fox Sports 1, use this channel finder.
UFC 166 Pay-Per-View: 10 p.m. ET
- Cain Velasquez vs. Junior dos Santos
- Daniel Cormier vs. Roy Nelson
- Gilbert Melendez vs. Diego Sanchez
- Gabriel Gonzaga vs. Shawn Jordan
- John Dodson vs. Darrell Montague
The UFC 166 pay-per-view will be available through UFC.tv.