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Look for Steven Davis to get his third-straight start for the Saints.
Attacking midfield is the one area of the Southampton lineup that gives Pochettino pause when filling out his team sheet each week.
Most weeks will see at least one high-priced signing forced to sit on the bench or, in some cases, not even making the squad at all.
One regular has been team captain Adam Lallana. The 25-year-old has been making a case for England inclusion with his recent play.
Lallana ranks in the top 20 in Premier League play with 1.9 key passes per match, and only Mesut Ozil has more assists (three) than Lallana's two so far this season, according to WhoScored.
Since arriving from Roma, Dani Osvaldo has also been a regular presence in the Saints lineup. While the Italian international has struggled to adapt to his new surroundings and position a bit, one cannot deny the class and flair Osvaldo can bring to the pitch.
The final position is up for grabs. Jay Rodriguez, James Ward-Prowse and Gaston Ramirez have all had opportunities to make the position their own this season. But the current in-form choice is Steven Davis.
Davis has started in each of the last two matches, both 2-0 victories over Crystal Palace and Swansea. The former Rangers captain assisted on Adam Lallana's goal against Swansea and scored a goal of his own for Northern Ireland against Israel on Tuesday.
With Pochettino most likely wanting to apply maximum pressure on Manchester United, Davis makes the most sense, being the most defensively-minded option at the position.
The 28-year-old averages 1.0 tackles and 0.6 interceptions per match, according to WhoScored. Rodriguez, Ward-Prowse or Ramirez can't match him in either category.