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Here's a hypothetical lineup for Game 5, including how those batters have fared against Jon Lester in their careers.
CF: Austin Jackson (4-for-14, one double, one BB, two K)
RF: Torii Hunter (11-for-23, three doubles, three K)
3B: Miguel Cabrera (10-for-19, two doubles, one home run, five BB, one K)
1B: Prince Fielder (4-for-15, one BB, three K)
DH: Victor Martinez (6-for-13, one triple, one home run, two BB)
SS: Jhonny Peralta (7-for-25, one double, two home runs, five BBs, seven K)
C: Alex Avila (3-for-6, one double, two K)
LF: Andy Dirks (1-for-2, one home run, one BB)
2B: Omar Infante (2-for-6)
Total: 48-for-123 (.390) with eight doubles, one triple, five home runs, 15 BB and 18 K.
When Prince Fielder has a .267 career batting average against you and he's your primary source of relief in an opponent's lineup, chances are you're headed for a long day.
Lester's final line in Game 1 (6.1 IP, 6 H, 1 ER, 1 BB, 4 K) was pretty solid, but there were a lot of line drives, and all four of those strikeouts occurred in the first two innings. He was lucky to get out of jams in both the fifth and sixth innings without too much damage.
The odds are in favor of Detroit putting men on base with a fair amount of regularity. Whether they're able to win the game will likely depend on their ability to convert with runners in scoring position after going 1-for-11 in Game 1.