Upsets are a part of the fabric of the NFL, and this week's slate of games should provide chances for upsets in various matchups across the board.
Denver, Kansas City and New Orleans have the biggest targets on their backs after all starting the year 5-0, but there are a number of other teams that need to treat Week 6 like a playoff game to avoid adding a number in the loss column.
Even the winless New York Giants took the Chicago Bears to the brink on Thursday night, a stark reminder that anything can happen on any given game day.
We'll take a look at three matchups with upset potential below and also provide you with a complete set of predictions for the remaining NFL games on the weekend schedule.
Complete Week 6 NFL Picks
Projected Scores for Potential Upset Games
Seattle Seahawks 21, Tennessee Titans 20
The Seahawks opened up as a two-touchdown favorite in Las Vegas, but the Tennessee Titans have to feel disrespected as a group after looking at the odds for their Week 6 game.
Coming off their first loss of the season—a 34-28 contest in favor of the Indianapolis Colts—there's little doubt that the Seahawks will be motivated to turn things around at home against the Titans.
In two home games at CenturyLink Field this season, Seattle has won by an average of 27 points.
That certainly has something to do with the big spread, as does the fact that one of those wins was against division rival San Francisco. The Seahawks are a different team at home. There's no doubt about that.
However, Tennessee is an upstart team this year because of its defense. If it hadn't for some late heroics in Kansas City, we might be talking about the Titans as a 4-1 team.
I don't see Seattle blowing this game at home, but I would take the points if you're into sports betting. Tennessee has weapons on offense, and Ryan Fitzpatrick has shown life as an NFL starter since taking over for Jake Locker.
A late defensive stand and a home-field edge are the difference in a tight Seattle win.
Houston Texans 35, St. Louis Rams 21
Houston is in a precarious position heading into Week 6.
Coming off an embarrassing loss to the San Francisco 49ers and three total losses in a row, the Texans are losing patience with Matt Schaub and have questions to answer on both sides of the ball to boot.
Although the St. Louis Rams are an opponent that has the resume of the Niners, Seahawks or Baltimore Ravens, they are a dangerous team backed into the corner of being in a division where mounting losses equals an early end to the season.
Sam Bradford has been one of the league's most underrated passers through five weeks, and his confidence will be high after shredding the Jacksonville Jaguars.
However, the Texans are in a situation where they desperately need a win. Backed against a wall itself, expect Houston to rely on the running game and take the ball out of Schaub's hands as much as possible early on.
The Rams struggle at defending the run, and Arian Foster and Ben Tate each score a touchdown as the Texans manage to stop the bleeding.
Detroit Lions 31, Cleveland Browns 28
The Browns are underdogs at home this week, but have won their last three games and are currently in a three-way tie for the top spot in the AFC North.
With Detroit coming to town, there's a very real possibility that Cleveland gets win No. 4 in a row.
The Lions have been one of the NFL's bottom-tier teams when it comes to stopping the pass, and that bodes well for a Browns offense that will feature Brandon Weeden at quarterback on Sunday. With Josh Gordon, Jordan Cameron and Willis McGahee in complementary roles, Cleveland is a team that can beat you in different ways.
That said, the Lions also have an impressive offense in tow. Among Matthew Stafford, Reggie Bush and Calvin Johnson, the weapons in Detroit can also beat you at any given moment.
I like the Browns to take an early lead in this one, but in a shootout, the Lions remind us why they are an NFC North contender themselves a week after laying an egg against Green Bay.
So, there you have it. While there will invariably be an upset or two in the NFL this weekend, these aren't the three games to look for that result in on Sunday.
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