Some matchups are simply unfair. And for a handful of NFL teams in Week 6, defeat is all but certain.
The winless Jacksonville Jaguars are one team that's sure to flounder this weekend. The Jags will be 28-point underdogs in Denver, where they'll take on the unbeaten Broncos. Peyton Manning and company are averaging an astounding 46 points per game and should have an easy time covering the spread at home.
The good news for Jacksonville: They won't be alone.
Here, I'll highlight three other teams guaranteed to struggle on Sunday.
NFL Predictions Week 6
|Green Bay Packers||vs||Baltimore Ravens|
|Cincinnati Bengals||vs||Buffalo Bills|
|Detroit Lions||vs||Cleveland Browns|
|Kansas City Chiefs||vs||Oakland Raiders|
|Minnesota Vikings||vs||Carolina Panthers|
|Pittsburgh Steelers||vs||New York Jets|
|Philadelphia Eagles||vs||Tampa Bay Buccaneers|
|Houston Texans||vs||St. Louis Rams|
|Denver Broncos||vs||Jacksonville Jaguars|
|Seattle Seahawks||vs||Tennessee Titans|
|New Orleans Saints||vs||New England Patriots|
|San Francisco 49ers||vs||Arizona Cardinals|
|Dallas Cowboys||vs||Washington Redskins|
|Indianapolis Colts||vs||San Diego Chargers|
Oakland will be on the road in Week 6 to take on division rival Kansas City. But unlike Chiefs teams that the Raiders have faced in the past, this year's squad is a defensive-minded one that won't beat itself.
Andy Reid's Chiefs boast the best turnover differential in the league this season at plus-10 and possess the NFL's top scoring defense, allowing just over 11 points per game. No other team is allowing fewer than 14 per game.
Add in the fact that the Raiders are 0-2 on the road this season and it's not hard to see why Kansas City is a 10.5-point favorite to advance to 6-0 this weekend.
The Chiefs are rolling at the moment and Oakland is certain to be the next victim on Sunday.
The Titans will be without quarterback Jake Locker for the second straight week, but that'll be the least of their concerns on Sunday.
Tennessee will head west to Seattle, where the Seahawks haven't lost a game since December 2011. In 2013, Pete Carroll's Hawks are forcing four turnovers per game and winning by an average of 27 points at CenturyLink Field.
Those stats alone are scary enough, but keep in mind the fact that Seattle boasts the NFL's second-ranked rushing attack.
Watch for a Ryan Fitzpatrick-led Titans offense to struggle in hostile territory, where even the Seahawks' offensive unit sometimes has trouble avoiding false starts.
Thanks to some lackluster competition over the past two weeks, the Arizona Cardinals are only one game back in the loaded NFC West. Unfortunately, Carson Palmer and company will be on the road against surging San Francisco on Sunday afternoon in a game the Cardinals are sure to lose.
Which of these teams is the biggest lock to lose?
After all, the Niners have rebounded from a sluggish start to win two in a row and are allowing just seven points per game over that stretch.
Offensively, San Francisco has been solid as well, scoring at least 34 points in each of those victories.
On the other side, Palmer has thrown a combined seven interceptions to just two touchdowns over the past three games. That level of play may be good enough to beat the likes of Tampa Bay and Carolina, but look for the 49ers' second-ranked secondary to take advantage of Arizona's sloppy offensive play and generate a few turnovers.
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