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Defense must create opportunities
Buffalo has one of the most opportunistic defenses, forcing 11 takeaways and generating 18 sacks. Dalton and the Cincinnati offense have been underwhelming this year so far and should give Buffalo's defense plenty of chances to give the ball back to Lewis.
Lewis needs to play smart
Last week, Cincinnati's defense contained Tom Brady, sacking him four times, hitting him another eight and putting Brady under near-constant pressure. This was without key players Leon Hall and Michael Johnson, who will likely return this week.
Lewis needs to protect the ball and not force it into small windows as inexperienced quarterbacks are apt to do. Additionally, Lewis must maintain constant pocket awareness and never flinch in the face of Cincinnati's fearsome pass rush.
Big performances from C.J. Spiller and Fred Jackson
Buffalo's offensive strength is its run game. In order to win, Spiller and Jackson need to provide immense support to Lewis, which is easier said than done against a top-11 run defense. To make matters worse, Spiller is still hindered by injury and Jackson can't shoulder the same kind of load as before.
If one or both running backs break the century mark, Buffalo has a chance to win.