The NFL's Week 6 schedule features a few mismatches, as top teams take on inferior opponents.
As such, there are a few monster spreads available for gambling purposes, but it would be foolish to count out the underdog in some of these fights.
Before going any further, let's get this out of the way: The Jacksonville Jaguars won't cover the spread when they take on the Denver Broncos, no matter how high it is when the game kicks off at 4:05 p.m. ET.
Jacksonville is the worst team in the league, and the Broncos could trot out Brock Osweiler instead of Peyton Manning and still walk away with the victory.
These upcoming teams, however, will not go down easy and are sure to cover the spread.
Note: Odds courtesy of Covers.
Oakland Raiders at Kansas City Chiefs (-9.5)
Nobody should be surprised if this game is decided by three points or less.
The Kansas City Chiefs don't feature an offense that puts up points in bunches, relying more on a methodical approach with the efficient Alex Smith playing mistake-free football.
Kansas City's defense has been the biggest reason the Chiefs are 5-0 to open the season. This unit leads the league in sacks, but Terrelle Pryor is a difficult quarterback to contain.
The Raiders have been highly competitive in every game this year, thanks to Pryor's ability to make plays off the cuff and thanks to an underrated defense that never says die.
The only real lapse came against the Washington Redskins in Week 4, but Matt Flynn was horrible in place of Pryor, who was out with a concussion.
Not counting Oakland's 16-point loss to the Broncos in Week 3, the Raiders are plus-six in points for the season.
The Chiefs have the better team and should win this game at home, but it won't be a blowout.
Tennessee Titans at Seattle Seahawks (-13.5)
Even without Jake Locker, the Tennessee Titans are a tough team.
The Chiefs were able to win by nine points last weekend, thanks in part to three turnovers by the Titans. But Ryan Fitzpatrick showed some pluck against the league's top-ranked pass-rushing defense, engineering a couple of touchdown drives under heavy pressure.
Russell Wilson has thrown an interception in four straight games, dating back to Week 2 at home against the San Francisco 49ers.
Tennessee's defense is among the best in the league at creating turnovers, with 11 for the season. It is also one of the NFL's top-rated scoring defenses, allowing just 19 points per game.
The "12th Man" in Seattle will make life difficult for Fitzpatrick and Tennessee's offense, but the feisty Titans defense will keep the team in the game until the end.
Arizona Cardinals at San Francisco 49ers (-10.5)
Physicality is the name of the game this weekend when the Cardinals take on the 49ers at Candlestick Park.
Both teams enter Week 6 with records of 3-2—one game behind the Seahawks in the NFC West.
Arizona's defense has been impressive this season, allowing just 19 points per game while forcing 11 turnovers. San Francisco has turned the ball over nine times already this year, though the team has improved the past two weeks in this category with just two.
The biggest key for Arizona will be whether or not Carson Palmer will take care of the ball. He's already thrown nine interceptions—including three in last week's contest against the Carolina Panthers.
The 49ers have been vulnerable against the run this season, allowing 113.6 rushing yards per game. Rashard Mendenhall will have success if he's given a chance to make plays between the tackles, and the Cardinals will keep the game close as a result.
The 49ers will win at home, but it'll be a nail-biter that's won by a touchdown or less.
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