Each week features stars that are risky picks, and quarterback Tony Romo is one player who fantasy owners are wondering what to do with.
While these players are usually good picks, this week's matchups may or may not be favorable. The players on this list will be good starts or bad choices based on who they play in Week 6.
Things are starting to get tougher for fantasy owners as they start to deal with bye weeks. Players like Matt Ryan and Mike Wallace are off this week, so some owners may need some help deciding who they should start.
Below is a group of players and what you should do with them this week.
Tony Romo, QB, Dallas Cowboys
After last week's incredible performance, most fantasy owners who own Tony Romo won't even think twice about starting him. The 33-year-old threw for 506 yards with five touchdowns last week. That is about as good as it gets in fantasy leagues.
The veteran has thrown for 1,523 yards with 13 touchdowns to only two interceptions in 2013.
Now the Washington Redskins come to town on Sunday night. Against Washington last season, Romo threw five touchdowns but also had five interceptions in two games.
He didn't have much success against them last season, but he is poised for a big game this week. Washington owns the fifth-worst pass defense. The secondary is tied for the fourth-fewest number of interceptions and tied for 10th in touchdowns allowed. Washington is also tied for 26th in points allowed.
Dallas owns the seventh-best passing attack and has thrown for the second-most touchdowns in football.
Romo may not get the type of numbers that he put up last week, but he is due for a big week. The days of worrying about him are over, so put him in the lineup.
Verdict: Start 'em
Trent Richardson, RB, Indianapolis Colts
Although this looked like a great deal from the start, Trent Richardson has had a hard time being productive with the Indianapolis Colts.
The 22-year-old has only 151 rushing yards and six receiving yards since joining the team. He has averaged only three yards per carry with the Colts but has scored two touchdowns.
Indianapolis suffered a big loss this week as Mike Wells of ESPN.com reported that Ahmad Bradshaw will miss the rest of the season after neck surgery. It's not the ideal situation, but his absence will lead to more touches for Richardson.
His Week 6 opponent, the San Diego Chargers, rank 24th against the run. The Chargers have allowed 4.9 yards per carry, so this could be a big breakout game for the former first-round pick.
Richardson has yet to top 60 rushing yards with Indianapolis. This will be his week to show why the Colts acquired him, and he should be more involved with the passing game as well. He has only one catch in the last three weeks, but he has 59 receptions in his career.
Give Richardson another week or so before you think about pulling him out of your lineup.
Verdict: Start 'em
Calvin Johnson, WR, Detroit Lions
Is this even a question? Actually, it is.
Calvin Johnson's status is up in the air right now, and his knee injury will limit him if he plays. The superstar sat out last week's game in Green Bay, but he may return for this week's game in Cleveland.
The Browns have a very underrated defense. With Joe Haden and T.J. Ward in the secondary, opposing wideouts have trouble being productive. Mike Wallace of the Miami Dolphins had only one catch against Cleveland in Week 1, and Cincinnati Bengals star A.J. Green had seven receptions for only 51 yards against the Browns earlier this year.
Cleveland ranks seventh against the pass. Its 19 sacks is tied for the third-most in the league, and the pressure forces quarterbacks to make poor decisions.
Johnson has two 100-yard games this season and has at least one touchdown in three straight games—that he played in.
His status is up in the air right now, and his talent is tough to bench. However, the combination of his injury and his opponent should have fantasy owners nervous.
Verdict: Sit 'em
*All stats are courtesy of NFL.com