Since the Atlanta Falcons and Miami Dolphins have bye weeks in Week 6, it's inevitable that some owners will be left out in the cold as key players take the week off.
For others, finding a solution at a certain position is a necessity. Some players haven't lived up to expectations or are unable to play altogether thanks to injuries.
Whatever the case may be, there are plenty of solid players out there to take a chance on this week.
Here are some who qualify as must-start options in Week 6.
Quarterback: Nick Foles, Philadelphia Eagles
With Michael Vick listed as questionable with a hamstring injury, per ESPN, Nick Foles has a shot to make a start this Sunday against the Tampa Bay Buccaneers.
Adding to that, head coach Chip Kelly made it clear Vick's job is by no means safe and he hasn't decided on a starter, according to USA Today.
So it'll be wise to keep an eye on the Eagles' ever-evolving quarterback situation, but should Foles get the nod, he is a must-start. After entering the game for the injured Vick last week against the New York Giants, Foles finished the Eagles' win by completing 16 of 25 passes for 197 yards and two scores.
Not to mention, the Eagles' Week 6 opponents, the Tampa Bay Buccaneers, are only decent against the pass with a No. 15 ranking, while the Eagles own the No. 11 passing attack in the NFL.
Foles is a better pocket passer than Vick, so expect those team numbers to improve with Foles behind center.
Availability: Owned in 0.5 percent of ESPN leagues
Running Back: Zac Stacy, St. Louis Rams
For a team in desperate need of production at running back, Zac Stacy delivered for the Rams last week with 78 yards on 14 carries.
It wasn't a great game—it came against the lowly Jacksonville Jaguars' horrid defense—but running backs are hard to come by this late in the season. Stacy figures to get a starter's looks after an impressive showing.
Stacy is listed as questionable for the Rams game against the Houston Texans on Sunday, per ESPN. Should he take the field, he'll probably end up getting the start against the Texans. Owners would be wise to give Stacy a go; the Texans are ranked No. 27 against the run this season.
Availability: Owned in 1.2 percent of ESPN leagues
Wide Receiver: Ted Ginn, Carolina Panthers
Ted Ginn may be tied for third on the Carolina Panthers with just 11 receptions and just fourth in the targets department with 18, but he is still second on the team in receiving yards (221) and tied for first in touchdowns (two). Ginn also has big-play ability with four catches of 20 yards or more. His season-long reception is 47 yards.
Versatility is also a part of Ginn's game. He has returned five kickoffs and punts apiece, so he can score touchdowns in that facet of the game as well.
After three straight games of solid production, Ginn is primed for another against the Minnesota Vikings' No. 29-ranked pass defense.
Availability: Owned in 7.3 percent of ESPN leagues
Tight End: Sean McGrath, Kansas City Chiefs
With nine receptions for 118 yards and a score in two weeks, Sean McGrath is starting to become a regular player in the Kansas City Chiefs offense. Overall, McGrath is fourth on the team in receptions (15) and receiving yards (180), and his four plays of 20 yards or more are second-best.
That means McGrath can gain yards quickly and put up solid points. A favorable matchup against the Oakland Raiders' No. 21-ranked pass defense should add some extra incentive to give him a look this week.
Availability: Owned in 3.5 percent of ESPN leagues
Defense/Special Teams: Detroit Lions
Despite a zero-point performance last week against the Green Bay Packers, the Detroit Lions have been a serviceable defense this season, with their best point total being 13 in Week 4. Aside from last week, the fewest points this defense has scored is six.
Plenty of points are to be had in Week 6 as the Lions take on the Cleveland Browns.
Not only do the Browns own the No. 17 air attack and No. 24 ground game, but they also have allowed the second-most sacks in the NFL.
And mistake-prone Brandon Weeden will be behind center.
Availability: Owned in 6.6 percent of ESPN leagues
Kicker: Nick Folk, New York Jets
Now that the Jets appear to have a pulse offensively, that's a good sign for Folk getting more field-goal tries and more points as a result. Folk dropped 13 in ESPN leagues last week, including a game-winning field goal that shows he can make kicks in any situation as the Folk hero.
The Jets' Week 6 opponent, the Pittsburgh Steelers, have allowed 11 points to kickers three times this season, with the lowest total coming in Week 2 against the Cincinnati Bengals (nine). New York's offense is still far from a certainty, so Folk should have plenty of field-goal chances should Geno Smith and company fall short on drives.
Availability: Owned in 2.1 percent of ESPN leagues