Picking the right quarterback to start on your fantasy football team is key to winning games.
Coming up in Week 6, Peyton Manning owners are giddy at the prospect of their signal-caller going ham on the hopeless Jacksonville Jaguars.
Ryan doesn't play in Week 6, however, as the Atlanta Falcons are on their bye week. This gives fantasy owners a week to try to figure out what to do now that he's lost his top weapon for the season.
With that in mind, here's a look at the best and worst quarterback plays for this upcoming weekend of NFL football.
Start 'Em: Andrew Luck at San Diego Chargers
There's no way to sugar-coat the horror show that is San Diego's defensive secondary.
Only five teams in the league have allowed more passing yards per game than the Chargers. This unit has given up 10 touchdown passes and ranks as the second-worst team in the NFL in allowing fantasy points to opposing quarterbacks.
Andrew Luck, fresh off his brilliant performance against the Seattle, which features the league's best secondary, will have a field day against the Chargers on national television.
Reggie Wayne should break out of his current slump, and T.Y. Hilton will build off his monster game against the Seahawks.
Projected stats: 300 passing yards with three touchdowns and 40 rushing yards.
Sit 'Em: Carson Palmer at San Francisco 49ers
Carson Palmer hasn't been the breath of fresh air the Arizona Cardinals hoped he'd be when they signed him this past offseason.
Through five games, Palmer has thrown just five touchdown passes while tossing nine interceptions.
If you're relying on Palmer to start for your fantasy team, you're in trouble—especially this weekend, when the Cardinals travel to Candlestick Park to take on the San Francisco 49ers.
Even without Aldon Smith and Patrick Willis, the 49ers have been one of the league's best teams against the pass this season. Opposing offenses are gaining just 189 yards on average, which is stunning considering Aaron Rodgers went off for 333 yards in Week 1.
Opposing quarterbacks are averaging just 13.3 fantasy points per week, which is the third-best mark in the league.
This doesn't bode well for Palmer and the Cardinals.
Projected stats: 200 passing yards with one touchdown and two interceptions.
Start 'Em: Tony Romo vs. Washington Redskins
Tony Romo is a must-start fantasy quarterback every single week, but the matchup against the Washington Redskins this Sunday is worth highlighting.
Washington gives up the fourth-most fantasy points to opposing quarterbacks, and Romo is coming off a career game against the Denver Broncos in which he passed for 506 yards and five touchdowns.
Dez Bryant, Jason Witten, Terrance Williams and the rest of Romo's receivers will find themselves wide open all game long against Washington's porous secondary.
He might not hit 500 yards again, but Romo is set to go off in front of a national audience on Sunday Night Football.
Projected stats: 375 passing yards with three touchdowns and one interception and 30 rushing yards.
Sit 'Em: Terrelle Pryor at Kansas City Chiefs
Terrelle Pryor had a career game against the Chargers while most of the nation slept late on Sunday night, but he'll have a tougher go of it in Week 6.
The Kansas City Chiefs have terrorized opposing quarterbacks all year long. They lead the league with 21 sacks through five games and rank No. 4 in passing defense, allowing just 198 yards per game. The team has also forced seven interceptions.
These stats translate to opposing quarterbacks scoring just 11.4 fantasy points per game against this unit, which ranks No. 5 in the league.
The Chiefs enter Week 6 with an undefeated record, and the always-rabid crowd at Arrowhead Stadium will be raucous for this rivalry game.
Pryor will struggle badly in the hostile environment and turn the ball over a couple of times, to the doom of the Raiders and his fantasy owners.
Projected stats: 180 passing yards with one touchdown and two interceptions and 30 rushing yards with one lost fumble.
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