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Danny Woodhead vs. Indianapolis
You can run on Indy, sure. The Colts have given up the second-most yards on the ground in the NFL so far this year and four touchdowns to boot. However, Woodhead's value is in the passing game more than rushing the ball, and that's where he'll net you some good point totals. If Ryan Mathews does not pass concussion protocol, Woodhead will split time with Ronnie Brown, who would also become an interesting start.
DeAngelo Williams vs. Minnesota
The Vikings are ranked well against the run, but they are allowing an average of 108 yards per game right now, and while the Panthers offense seems to be a hot mess, Williams is an effective runner with a great matchup here and no competition for carries. He should be a solid No. 2 running back with upside.
Bilal Powell/Mike Goodson/Chris Ivory vs. Pittsburgh
Yes, we're all very excited by the excellent game Geno Smith had, but the truth is that a solid run game was a big help. While none of the three main Jets running backs broke 50 yards, they all carried the ball well, and the Steelers defense gives up an average of 122 yards per game while also allowing the second-most touchdowns on the ground in the NFL.
Now, you can't rely on these backs as more than a flex because this is absolutely a committee. However, all three will get opportunities against a defense which can be run on, and run on hard. Goodson and Powell both got targets in the passing game as well and are on the field more (according to the Gamebook, Powell was on the field for 74 percent of the offensive snaps, compared to 24 for Goodson and 17 for Ivory). More than likely, Ivory is being eased back in, but it seems as though your best flex bets are Powell and, to a lesser extent, Goodson.